|
KMID : 0358420070500081115
|
|
Korean Journal of Obstetrics and Gynecology
2007 Volume.50 No. 8 p.1115 ~ p.1124
|
|
|
Association of LRP5 gene polymorphisms with bone mineral density and bone responsiveness to hormone therapy in postmenopausal Korean women
|
|
Han Chan-Hee
Kwon Dong-Jin
Kim Jin-Hong
|
|
|
Abstract
|
|
|
Objective: To evaluate the association of LRP5 gene polymorphisms with bone mineral density (BMD) and bone responsiveness to hormone therapy (HT) in postmenopausal women.
Design and Methods: The LRP5 gene polymorphisms were analyzed by restriction fragment length polymorphism (RFLP) in 229 postmenopausal women receiving HT for 1 year. The BMD before HT was check using dual-energy x-ray absorptiometer (DEXA) at lumar spine, femur neck, Ward’s triangle, and greater trochanter of femur, and women in the study were classificed into 3 group, normal, osteopenia and osteroporosis according to their BMD.
Results: The frequency of genotype C/C of C1677A was significanty high in osteoporosis group, and that of C/A was much low in osteoporosis group. The frequency of genotype T/C of T2268C was high in osteoporosis group, while that of C/C was low in the same group. There was no significant relationship between LRP5 polymorphisms and BMD before HT. In patients whose genotype was A/A of C3405G, C/C of T2268C, or C/C of T4037C had meaningful responsiveness to HT at the lumbar spine, regardless of their initial BMD. The Genotype C/A of C1677A also had great responsiveness to HT at the greater trochanter of femur in both osteopenia and osteoporis group.
Conclusion: The LRP5 gene polymorphisms were not associated with the BMD before HT, but there were some reponsiveness to HT at specific site according to genotypes of the gene.
|
|
|
KEYWORD
|
|
|
LRP5, Polymorphism, Osteoporosis, HT
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
  
|
|